5-tert-Butyl-2-(3-(5-(1-ethyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one → 5-tert-Butyl-2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridazin-3-yl)phenyl)isoindolin-1-one
반응식
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[N:9]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]3[CH:26]=[C:25]([NH:27][C:28]4[CH:32]=[CH:31][N:30]([CH2:33]C)[N:29]=4)[C:24](=[O:35])[N:23]([CH3:36])[N:22]=3)[C:16]=1[CH2:37][OH:38])[CH2:8]2)([CH3:4])([CH3:3])[CH3:2].ClC1C=C(NC2C=CN=CN=2)C(=O)N(C)N=1.C(OCC1C(B2OC(C)(C)C(C)(C)O2)=CC=CC=1N1CC2C(=CC=C(C(C)(C)C)C=2)C1=O)(=O)C>>[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[N:9]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]3[CH:26]=[C:25]([NH:27][C:28]4[CH:32]=[CH:31][N:30]=[CH:33][N:29]=4)[C:24](=[O:35])[N:23]([CH3:36])[N:22]=3)[C:16]=1[CH2:37][OH:38])[CH2:8]2)([CH3:3])([CH3:4])[CH3:2]참가 물질
4
반응물 3
HCID 569290585-tert-Butyl-2-(3-(5-(1-ethyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one
HCID 666102376-Chloro-2-methyl-4-(pyrimidin-4-ylamino)pyridazin-3(2H)-one
HCID 866979362-(5-tert-Butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Acetate생성물 1
실험 절차
Using the same general procedure as described for the preparation of 102, reaction of 103b (192 mg, 0.810 mmol) with 102f (413 mg, 0.891 mmol) afforded 103 in 49% yield (196 mg) as an amorphous off-white solid: mp 236-238° C.; 1H NMR (500 MHz, DMSO-d6) δ 9.87 (s, 1H), 8.81 (s, 1H), 8.68 (s, 1H), 8.49 (d, J=6.0 Hz, 1H), 7.73 (d, J=8.0 Hz, 2H), 7.62 (dd, J=8.0, 1.5 Hz, 1H), 7.55-7.53 (m, 3H), 7.52-7.47 (m, 1H), 4.93 (s, 2H), 4.73 (t, J=5.0 Hz, 1H), 4.42 (d, J=5.5 Hz, 2H), 3.80 (s, 3H), 1.36 (s, 9H); MS (ESI+) m/z 497.2 (M+H).
출처 및 근거
- ORD 기록
- ord-aaacdb7b4420428c8b7ea176c38584d3
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08975260B2
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