4-nitrophenyl (2S)-1,1,1-trifluoropropan-2-yl carbonate → HCID 90019782, compound

HRID 872211Notes

Reaction equation

HRID 872211 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][C@H:18]([CH:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[F:26][C:27]([F:44])([F:43])[C@@H:28]([O:30][C:31](=O)[O:32]C1C=CC([N+]([O-])=O)=CC=1)[CH3:29]>>[F:26][C:27]([F:44])([F:43])[C@@H:28]([O:30][C:31]([N:23]1[CH2:24][CH2:25][CH:20]([C@@H:18]2[O:17][C:14]3=[CH:15][N:16]=[C:11]([C:8]4[CH2:9][CH2:10][N:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH2:6][CH:7]=4)[CH:12]=[C:13]3[CH2:19]2)[CH2:21][CH2:22]1)=[O:32])[CH3:29]

Participants

3

Reactant 2

HCID 687562104-nitrophenyl (2S)-1,1,1-trifluoropropan-2-yl carbonateHCID 71208337HCID 71208337, compound

Product 1

HCID 90019782HCID 90019782, compound

Procedure

The title compound is prepared from (R)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine and carbonic acid 4-nitro-phenyl ester (S)-2,2,2-trifluoro-1-methyl-ethyl ester following a procedure analogous to that described for Example 1. LC (method 1): tR=0.86 min; Mass spectrum (ESI+): m/z=504 [M+H]+.

Sources & evidence

ORD record
ord-d02a05ff133b450bb164c48948f77fa5
Source dataset
uspto-grants-2015_03
Patent number
US08975277B2

Reaction notes

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