HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropane → 7-Chloro-5-iodo-8-[(propan-2-yl)oxy]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | 7-Chloro-5-iodo-8-quinolinol | HCID 141944 | — |
| Product | 7-Chloro-5-iodo-8-[(propan-2-yl)oxy]quinoline | HCID 59756955 | 80% |
Reaction Steps
Following the procedure described in Example 8, 7-chloro-5-iodo-8-hydroxy-quinoline 20 and 2-bromopropane gave 7-chloro-5-iodo-8-isopropoxy-quinoline 21 (80%). 1H NMR (CDCl3/DMSO-d6 (19:1), 400 MHz): δ 9.09 (m, 1 H), 8.55 (m, 1 H), 8.10 (s, 1 H), 7.63 (m, 1 H), 5.15 (m, 1 H), 1.49 (s, 3 H), 1.47 (s, 3 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975278B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-1f67070450cb42988d30276df3c3854e |
| Source note | uspto-grants-2015_03 |