HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron Trichloride → HCID 57939302, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron Trichloride | HCID 25135 | — |
| Reactant | 7-Chloro-8-[(propan-2-yl)oxy]-5-(pyridin-3-yl)quinoline | HCID 57939358 | — |
| Product | HCID 57939302 | HCID 57939302 | 94.6% |
Reaction Steps
Cleavage of the isopropyl ether 22 (20 mg, 0.07 mmol) with boron trichloride following the method outlined in Example 8, gave 7-chloro-5-(pyridin-3-yl)-quinolin-8-ol (PBT 1057) as a pale straw-coloured solid (17 mg, 94%). 1H NMR (CD3OD, 400 MHz): δ 9.16 (m, 2 H), 9.04 (d, J=5.8, 1 H), 8.93 (dd, J=1.2 and 8.6, 1 H), 8.84 (m, 1 H), 8.30 (dd, J=5.8 and 8.1, 1 H), 8.09 (s, 1 H), 8.08 (dd, J=5.1 and 8.6, 1 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975278B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-3d9d3217ef2f4000ac09396326e50433 |
| Source note | uspto-grants-2015_03 |