Potassium Carbonate → HCID 50996184, compound

Participants

Reaction Steps

A mixture of 4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-ol (3-5, 25 mg, 0.12 mmol, 1 equiv), 2-chloropyridine-3-carbonitrile (76 mg, 0.62 mmol, 5.0 equiv) and potassium carbonate (34 mg, 0.25 mmol, 5.0 equiv) in acetonitrile (3 mL) was irradiated at 170° C. in microwave reactor for 10 min. The mixture was purified by silica gel chromatography (0 to 100% ethyl acetate in hexanes) to give 2-{[4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile (1) as a white solid. 1H NMR (300 MHz, CDCl3) δ 8.26 (dd, 1H, J=4.9, 1.8 Hz), 8.08 (dd, 1H, J=7.3, 1.8 Hz), 7.54 (d, 1H, J=8.8 Hz), 7.39 (d, 1H, J=8.8 Hz), 7.15 (dd, 1H, J=7.3, 4.9 Hz), 4.66 (d, 2H, J=7.3 Hz), 3.00 (p, 1H, J=7.3 Hz), 2.11 (m, 2H), 1.92 (m, 4H) ppm. LRMS m/z (M+H) 386.0 found, 386.0 required.

Provenance & Evidence