HRID872310

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22271407

5-Bromo-3-methoxypyridin-2-amine

C6H7BrN2O

结构：COC(=O)c1cc(Cl)c2nc(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)n2c1

HCID66665474

未命名化合物

PRODUCTS

生成物

结构：COc1cc(Br)cn2c(-c3ccccc3)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)nc12

HCID66665611

未命名化合物

PROCEDURE

实验过程

This intermediate was prepared in analogy to 2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-8-chloro-3-phenyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester by using 5-bromo-3-methoxy-pyridin-2-ylamine from Step 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3ca13f998c1441bbace4eea7e2a9907
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08975265B2
来源说明: uspto-grants-2015_03

反应 SMILES

COC(C1C=C(Cl)C2N([C:11]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]4([NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:23][CH2:22][CH2:21]4)=[CH:16][CH:15]=3)N=2)C=1)=O.[Br:39][C:40]1[CH:41]=[C:42]([O:47][CH3:48])[C:43]([NH2:46])=[N:44][CH:45]=1>>[C:28]([O:27][C:25](=[O:26])[NH:24][C:20]1([C:17]2[CH:16]=[CH:15][C:14]([C:12]3[N:46]=[C:43]4[C:42]([O:47][CH3:48])=[CH:41][C:40]([Br:39])=[CH:45][N:44]4[C:11]=3[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:19][CH:18]=2)[CH2:21][CH2:22][CH2:23]1)([CH3:31])([CH3:29])[CH3:30]