5-Bromo-3-methoxypyridin-2-amine → HCID 66665611, compound

HRID 872310Notes

Reaction equation

HRID 872310 reaction equation
COC(C1C=C(Cl)C2N([C:11]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]4([NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:23][CH2:22][CH2:21]4)=[CH:16][CH:15]=3)N=2)C=1)=O.[Br:39][C:40]1[CH:41]=[C:42]([O:47][CH3:48])[C:43]([NH2:46])=[N:44][CH:45]=1>>[C:28]([O:27][C:25](=[O:26])[NH:24][C:20]1([C:17]2[CH:16]=[CH:15][C:14]([C:12]3[N:46]=[C:43]4[C:42]([O:47][CH3:48])=[CH:41][C:40]([Br:39])=[CH:45][N:44]4[C:11]=3[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:19][CH:18]=2)[CH2:21][CH2:22][CH2:23]1)([CH3:31])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 222714075-Bromo-3-methoxypyridin-2-amineHCID 666654742-[4-(1-Tert-butoxycarbonylamino-cyclobutyl)-phenyl]-8-chloro-3-phenyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester

Product 1

HCID 66665611HCID 66665611, compound

Procedure

This intermediate was prepared in analogy to 2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-8-chloro-3-phenyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester by using 5-bromo-3-methoxy-pyridin-2-ylamine from Step 1.

Sources & evidence

ORD record
ord-b3ca13f998c1441bbace4eea7e2a9907
Source dataset
uspto-grants-2015_03
Patent number
US08975265B2

Reaction notes

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