Hydrochloric Acid → HCID 66666011, compound

Participants

Reaction Conditions

Reaction Steps

2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (0.76 g) was suspended in tert-butanol (19.2 mL) and treated with dilute aqueous sodium hydroxide solution (1M, 6.1 mL). The mixture was heated to 70° C. for 3.5 h. On cooling the reaction was diluted with water and the pH adjusted to 5 with dilute aqueous hydrochloric acid. The resulting emulsion was extracted with ethyl acetate and the organic extract washed with brine, dried and concentrated in vacuo to give the crude title compound which was used without further purification.

Provenance & Evidence