Triethylamine → HCID 66665523, compound

Participants

Reaction Conditions

Reaction Steps

A solution of {1-[4-(6-hydroxymethyl-3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (200 mg) in DCM (1.9 mL), was treated with triethylamine (0.062 mL), cooled to 0° C. (ice bath), treated with methanesulfonyl chloride (0.028 mL, 0.358 mmol) and stirred for 2 hours at rt. The reaction mixture was partitioned between DCM and saturated aqueous sodium hydrogen-carbonate solution and the organic phase washed with brine, dried and concentrated in vacuo to give the crude title compound.

Provenance & Evidence