Potassium Carbonate → {1-[4-(3-Phenyl-6-vinyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Participants

Reaction Conditions

Reaction Steps

A mixture of {1-[4-(6-bromo-3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (70 mg, 60% purity by UPLC-MS), potassium carbonate (11.2 mg), tetraethylammonium bromide (22.1 mg), tributylvinyl stannane (38.5 mg) and trans-dichlorobis(triphenylphosphine) palladium (II) (1.7 mg) in THF (0.66 mL) under argon was heated at 120° C. for 45 min. On cooling the reaction was partitioned between DCM and water, the organic extract dried and concentrated to give the crude title compound which was used without further purification.

Provenance & Evidence