(E)-3-{2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-7-yl}-acrylic acid methyl ester → 3-{2-[4-(1-Tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-7-yl}-propionic acid methyl ester

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A mixture of (E)-3-{2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-7-yl}-acrylic acid methyl ester (450 mg, 0.86 mmol) and 10% palladium on carbon (0.2 g) in MeOH (20 mL) was stirred under a hydrogen atmosphere for 2 h, and the resulting mixture was filtered. The resulting solution was concentrated under reduced pressure. The remaining material was purified using MPLC (Biotage Isolera; 25 g SNAP cartridge: gradient from 100% hexane to 80% hexane/20% EtOAc over 1.0 min., 80% hexane/20% EtOAc for 3 min., gradient to 50% hexane/50% EtOAc over 3.5 min., 50% hexane/50% EtOAc for 14.6 min,) to give 3-{2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-7-yl}-propionic acid methyl ester (208 mg, 46%):

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