反应详情

A solution of 2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (2.30 g, 4.60 mmol) in MeOH (77 mL) was added a solution of NaOH (3.7 g, 9.24 mmol, 2.0 equiv) in water (15 mL). The resulting mixture was stirred at room temperature for 12 h. The resulting clear solution was concentrated under pressure. The remaining material was treated with water (50 mL), made acidic with an aqueous 2N HCl solution, and extracted with a 4:1 CH2Cl2/isopropanol solution (4×25 mL). The combined organic phases were dried (Na2SO4 anh) and concentrated under reduced pressure to give 2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridine-7-carboxylic acid (2.4 g, 107%):

1. concentrationThe resulting clear solution was concentrated under pressure
2. additionThe remaining material was treated with water (50 mL)
3. extractionextracted with a 4:1 CH2Cl2/isopropanol solution (4×25 mL)
4. dry with materialThe combined organic phases were dried (Na2SO4 anh)
5. concentrationconcentrated under reduced pressure