HCID 66665651, compound → HCID 56645443, compound

Participants

Reaction Steps

81 mg (0.15 mmol) (1-{4-[8-(4-Fluorophenyl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl]-phenyl}-cyclobutyl)-carbamic acid tert.-butyl ester, intermediate example Int-300-0, were dissolved in 7 mL 4 M hydrogen chloride in dioxane. The reaction mixture was stirred over night at room temperature. After evaporation of the solvent the residue was dissolved in methanol and purified by chromatography on silicagel (amine phase, eluents: methanol/ammonia) followed by an additional chromatography (amine phase, eluents: ethyl acetate/hexane) yielding 38.2 mg (55.2%) of the title compound.

Provenance & Evidence