Hydrochloric Acid → HCID 56646651, compound

Participants

Reaction Steps

To a solution of {1-[4-(3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (50 mg, 0.11 mmol) in MeOH (0.45 mL) and CH2Cl2 (0.75 mL) was added a 4 molar solution of HCl in dioxane (0.57 mL, 2.2 mmol, 20 5equiv). The resulting solution was stirred at room temperature for 12 h, then was concentrated under reduced pressure. The remaining material was purified using MPLC (Biotage Isolera; 10 g SNAP cartridge: 100% CH2Cl2 4.0 min., gradient to 95% CH2Cl2/5% MeOH 9.5 min., gradient to 90% CH2Cl2/10% MeOH 6.1 min.) to give 1-[4-(3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutylamine (18 mg, 47%):

Provenance & Evidence