Hydrazine hydrate (1:1) → HCID 66665520, compound

Participants

Reaction Conditions

Reaction Steps

2-(2-{2-[4-(1-Amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyrimidin-7-yloxy}-ethyl)-isoindole-1,3-dione (340 mg from Step 1) was dissolved in ethanol (6.8 mL), treated with hydrazine hydrate (98%, 0.045 mL) and heated at 80° C. for 22 h. On cooling, the reaction mixture was diluted with diisopropyl ether and filtered. The filtrate was concentrated in vacuo to give the title compound (225 mg).

Provenance & Evidence