Hydrochloric Acid → HCID 66665870, compound

Participants

Reaction Steps

The crude product from Step 1 was dissolved in DCM/MeOH (1.2 mL/0.74 mL) and treated with HCl (4M solution in dioxane, 0.9 mL). The reaction was stirred at rt overnight before it was poured onto ice, made alkaline with dilute aqueous sodium hydroxide solution (2M) and extracted with DCM. The organic phase was washed with brine, dried and concentrated in vacuo. Purification was achieved by chromatography on silica gel to give the title compound (18 mg).

Provenance & Evidence