Water → HCID 66665201, compound

Participants

Reaction Steps

A mixture of 2-[4-(1-aminocyclobutyl)phenyl]-8-chloro-3-phenylimidazo[1,2-a]pyridine-6-carboxamide (see example 6-1, 100 mg, 0.17 mmol, 72% purity) and 1-propylphosphonic acid cyclic anhydride as 50%-solution in ethyl acetate (0.21 ml, 0.35 mmol) in 1.35 ml ethyl acetate were stirred at room temperature overnight. The reaction mixture was hydrolysed with water and extracted with ethyl acetate. The organic phase was filtered through a Whatman filter and the volatile components were removed by rotary evaporation. The crude material was purified by column chromatography (Snap cartridge, dichloromethane/ethanol 95/5->dichloromethane/ethanol 7/3) to give 11 mg of the title compound (16% overall yield).

Provenance & Evidence