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Dichloromethane → 4-(2-(4-Aminonaphthalen-1-yloxy)ethyl)pyridin-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 4-(2-(4-Nitronaphthalen-1-yloxy)ethyl)pyridin-3-amine | HCID 58416778 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(2-(4-Aminonaphthalen-1-yloxy)ethyl)pyridin-3-amine | HCID 58416779 | 96.8% |
反応手順
A solution of 4-(2-(4-nitronaphthalen-1-yloxy)ethyl)pyridin-3-amine (17) (700 mg, 2.263 mmol) in a mixture of MeOH (50 mL), EtOAc (25 mL), and DCM (25 mL) was passed through a Thales H-cube (10% Pt/C 30 mm, 1.0 mL·min−1, at 40° C., full hydrogen mode). The solvent was removed in vacuo to give 4-(2-(4-aminonaphthalen-1-yloxy)ethyl)pyridin-3-amine (18) as a brown solid (612 mg, 92%). m/z 280 (M+H)+ (ES+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08975285B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-ba8f03b9245041cda8826fd7b2087c05 |
| 出典メモ | uspto-grants-2015_03 |