1H-Indazole-3-carboxylic acid, 1-methyl- → 1-Methyl-1H-indazole-3-carboxylic acid{2-[5-(3,4-dichlorophenyl)furan-2-yl]ethyl}amide

Participants

Reaction Steps

The title compound was prepared as in Example 12 starting from N-methyl-indazole-3-carboxylic acid and 2-[5-(3,4-dichlorophenyl)furan-2-yl]ethylamine hydrochloride. The crude product was purified by flash chromatography using heptane/EtOAc as a gradient eluent (9:1-8:2). 1H NMR (400 MHz, DMSO-d6): 3.00 (2H, t), 3.64 (2H, m), 4.12 (3H, s), 6.36 (1H, d), 7.01 (1H, d), 7.26 (1H, m), 7.46 (1H, m), 7.600 (1H, s), 7.602 (1H, s), 7.72 (1H, d), 7.83 (1H, s), 8.16 (1H, d), 8.48 (1H, t).

Provenance & Evidence