反应详情

The title compound was prepared as in Example 12 starting from 4-imidazolecarboxylic acid and 2-[5-(3,4-dichlorophenyl)furan-2-yl]ethylamine hydrochloride. The crude product was purified by flash chromatography using CH2Cl2/MeOH as a gradient eluent (100:0-99.6:0.4). The product was triturated in ethyl acetate. 1H NMR (400 MHz, DMSO-d6): 2.93 (21-1, t), 3.55 (2H, m), 6.33 (1H, d), 7.01 (1H, d), 7.59 (1H, s), 7.63 (2H, s), 7.71 (1H, s), 7.87 (1H, s), 8.05 (1H, broad s), 12.43 (1H, broad s).

1. customThe crude product was purified by flash chromatography
2. customThe product was triturated in ethyl acetate