tert-Butyl N-(2-((methylsulfonyl)oxy)ethyl)carbamate → 4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)phthalonitrile

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Reaction Steps

The title compound was prepared from 4-(1H-pyrazol-5-yl)phthalonitrile (0.38 g) and 2-(tert-butoxycarbonylamino)ethyl methanesulfonate (0.61 g) using the method of Example 37(c). Yield 0.050 g (as HCl-salt). 1H-NMR (400 MHz; d4-MeOH): δ 3.50 (t, 2H), 4.54 (t, 2H), 6.94 (d, 1H), 7.81 (d, 1H), 7.98 (d, 1H), 8.28 (dd, 1H), 8.49 (d, 1H).

Provenance & Evidence