tert-butyl N-(2-hydroxyethyl)carbamate → HCID 67173246, compound

HRID 872550Notes

Reaction equation

HRID 872550 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:14][N:13]=[CH:12][CH:11]=2)=[CH:6][C:5]=1[C:15]([F:18])([F:17])[F:16])([O-:3])=[O:2].O[CH2:20][CH2:21][NH:22]C(=O)OC(C)(C)C>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][N:13]([CH2:20][CH2:21][NH2:22])[N:14]=2)=[CH:6][C:5]=1[C:15]([F:18])([F:17])[F:16])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 67171714HCID 67171714, compound

Product 1

HCID 67173246HCID 67173246, compoundYield 62.9%

Procedure

The title compound was prepared from 5-(4-nitro-3-(trifluoromethyl)phenyl)-1H-pyrazole (1.69 g, 6.57 mmol) and tert-butyl 2-hydroxyethylcarbamate (1.059 g, 6.57 mmol) using the method of Example 34(c) to afford 1.24 g of the title compound. 1H-NMR (400 MHz; d6-DMSO): δ 3.33 (m, 2H), 4.53 (t, 2H), 7.13 (d, 1H), 8.00 (d, 1H), 8.38 (m, 1H), 13.45 (m, 1H).

Sources & evidence

ORD record
ord-522fd1a67c68480da4032f83386a4eb2
Source dataset
uspto-grants-2015_03
Patent number
US08975254B2

Reaction notes

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