2-(Aminomethyl)-1H-imidazole-5-carboxylic acid, 2-BOC protected → HCID 86670244, compound

HRID 872603Notes

Reaction equation

HRID 872603 reaction equation
[NH2:1][C@H:2]([CH3:18])[CH2:3][N:4]1[CH:8]=[CH:7][C:6]([C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[C:11]([Cl:17])[CH:10]=2)=[N:5]1.[C:19]([O:23][C:24]([NH:26][CH2:27][C:28]1[NH:29][C:30]([C:33](O)=[O:34])=[CH:31][N:32]=1)=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[Cl:17][C:11]1[CH:10]=[C:9]([C:6]2[CH:7]=[CH:8][N:4]([CH2:3][C@H:2]([NH:1][C:33]([C:30]3[NH:29][C:28]([CH2:27][NH:26][C:24](=[O:25])[O:23][C:19]([CH3:21])([CH3:20])[CH3:22])=[N:32][CH:31]=3)=[O:34])[CH3:18])[N:5]=2)[CH:16]=[CH:15][C:12]=1[C:13]#[N:14]

Participants

3

Reactant 2

HCID 393457422-(Aminomethyl)-1H-imidazole-5-carboxylic acid, 2-BOC protectedHCID 67171309(R)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile

Product 1

HCID 86670244HCID 86670244, compound

Procedure

(R)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile (108 mg, 0.42 mmol) was coupled with 2-(tert-Butoxycarbonylaminomethyl)-1H-imidazole-5-carboxylic acid (100 mg, 0.42 mmol) using the method of Example 34(d). After extraction a quantitative yield of the title compound was obtained.

Sources & evidence

ORD record
ord-25089cc11179491196dc78b2aa05ca76
Source dataset
uspto-grants-2015_03
Patent number
US08975254B2

Reaction notes

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