反应详情

To a cooled (0° C.) solution of 4-amino-2-chloro-6-fluorobenzonitrile (3.55 g, 20.8 mmol), sulfuric acid (3.33 ml, 62.4 mmol), water (30 ml) and MeCN (100 ml) was added slowly a solution of sodium nitrite (1.58 g, 22.9 mmol) in water (10 ml). A solution of potassium iodide (6.91 g, 41.6 mmol) in water (10 ml) was added slowly while maintaining temperature of the reaction mixture below 10° C. After being stirred at RT for 2 h, the reaction was quenched by adding water (100 ml) and concentrating the mixture to about half of the original volume. The mixture was extracted with DCM (3×150 ml), and combined organic fractions were dried over Na2SO4 and evaporated to yield 4.77 g, (81%) of the title compound. 1H-NMR (400 MHz; d6-DMSO): δ 8.06 (dd, 1H), 8.08 (m, 1H).

1. temperaturewhile maintaining temperature of the reaction mixture below 10° C
2. customthe reaction was quenched
3. additionby adding water (100 ml)
4. concentrationconcentrating the mixture to about half of the original volume
5. extractionThe mixture was extracted with DCM (3×150 ml)
6. dry with materialwere dried over Na2SO4
7. customevaporated