HRID872709

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53399536

2-Bromo-1,3-oxazole-4-carboxylic acid

C4H2BrNO3

结构：C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1

HCID67170882

4-[1-[(2S)-2-Aminopropyl]-1H-pyrazol-3-yl]-2-chlorobenzonitrile

C13H13ClN4

PRODUCTS

生成物

结构：C[C@@H](Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1)NC(=O)c1coc(Br)n1

HCID70656701

未命名化合物

收率 12.4%

PROCEDURE

实验过程

(S)-2-bromo-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide was prepared using the method of Example 34(d) starting from (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile (741 mg, 2.82 mmol) and 2-bromooxazole-4-carboxylic acid (850 mg, 3.41 mmol). The product was purified by Flash-chromatography. Yield 12.4%. 1H-NMR (400 MHz; CDCl3): δ 1.20 (d, 3H), 4.18-4.47 (m, 2H), 4.51-4.65 (m, 1H), 6.64 (d, 1H), 7.48 (d, 1H), 7.72 (dd, 1H), 7.92-7.99 (m, 3H), 8.21 (s, 1H).

WORKUP

后处理

customThe product was purified by Flash-chromatography