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HRID872718

反应详情

EQUATION

反应方程式

HRID 872718 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1coc(Br)n1
HCID53399536

2-Bromo-1,3-oxazole-4-carboxylic acid

C4H2BrNO3

结构：Cc1c(-c2ccn(C[C@H](C)N)n2)ccc(C#N)c1Cl
HCID67171072

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(-c2ccn(C[C@H](C)NC(=O)c3coc(Br)n3)n2)ccc(C#N)c1Cl
HCID70657253

未命名化合物

收率 6.2%

PROCEDURE

实验过程

(S)-2-bromo-N-(1-(3-(3-chloro-4-cyano-2-methylphenyl)-1H-pyrazol-1-yl)-propan-2-yl)oxazole-4-carboxamide was prepared using the method of Example 34(d) starting from ((S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-3-methylbenzonitrile (742 mg, 2.70 mmol) and 2-bromooxazole-4-carboxylic acid (492 mg, 2.56 mmol). The product was purified by Flash-chromatography. Yield 6.2%. m/z [448.7+1].

WORKUP

后处理

  1. customThe product was purified by Flash-chromatography