Sodium Hydroxide → HCID 178524445, compound

HRID 872780Notes

Reaction equation

HRID 872780 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:12]=[C:11]([C:13]([O:15]CC)=[O:14])[NH:10][N:9]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[NH:10][N:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 178468981HCID 178468981, compound

Product 1

HCID 178524445HCID 178524445, compound

Procedure

The title compound was prepared from ethyl 3-(morpholinomethyl)-1H-pyrazole-5-carboxylate (0.138 g, 0.57 mmol) and sodium hydroxide solution (2 mL) using the method of Example 225(b). Yield 0.119 g. 1H NMR (400 MHz; MeOD): δ 3.22 (m, 2H), 3.46 (m, 2H), 3.78 (m, 2H), 4.05 (m, 2H), 4.43 (s, 2H), 7.05 (s, 1H).

Sources & evidence

ORD record
ord-0318ad2f4208440f88f8ecdacacdbbee
Source dataset
uspto-grants-2015_03
Patent number
US08975254B2

Reaction notes

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