Water → HCID 67168441, compound

HRID 872839Notes

Reaction equation

HRID 872839 reaction equation
I([O-])(=O)(=O)=O.[Na+].[OH2:7].[Br:8][C:9]1[O:13][C:12]([CH:14]([S:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:15][NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])=[CH:11][CH:10]=1>CO>[C:26]1([S:25]([CH:14]([C:12]2[O:13][C:9]([Br:8])=[CH:10][CH:11]=2)[CH2:15][NH:16][C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[O:18])=[O:7])[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

5

Reactant 3

HCID 962Water2×HCID 23667635Sodium periodate2×HCID 67168545HCID 67168545, compound

Product 1

HCID 67168441HCID 67168441, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium periodate (57 mg, 0.2677 mmol) in a small amount of water was added to pyridine-2-carboxylic acid [2-(5-bromofuran-2-yl)-2-phenylsulfanylethyl]-amide (90 mg, 0.2231 mmol) in methanol (13 ml). After refluxing for 4 h another 57 mg (0.2677 mmol) of sodium periodate was added and refluxing was continued for 4.5 h. Water (30 ml) was added and the product was extracted into EtOAc. The organic phase was washed with water, dried with Na2SO4 and evaporated. The crude product was used as such in the next step.

Workup

  1. additionwas added
  2. temperaturerefluxing
  3. extractionthe product was extracted into EtOAc
  4. washThe organic phase was washed with water
  5. dry with materialdried with Na2SO4
  6. customevaporated

Sources & evidence

ORD record
ord-abcc901da0e245ec917b35922d7d34e3
Source dataset
uspto-grants-2015_03
Patent number
US08975254B2

Reaction notes

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