反应详情

温度

0 °C

Ethyl 3-(1-trityl-1H-imidazol-4-yl)-1,2,4-oxadiazole-5-carboxylate (1.1 g, 2.442 mmol) was dissolved in ethanol (60 ml) and the resulting solution was cooled to 0° C. Cesium carbonate (6.36 g, 19.53 mmol) was dissolved in water (25 ml) and added into the solution. The reaction mixture was refluxed for 1 h. Ethanol was evaporated, diluted with water, filtered and washed with water. The solid was dried in vacuum at 40° C. The product was purified by recrystallization from THF and ethyl acetate, respectively. LC-MS: [M+1]=423.435.

1. additionadded into the solution
2. temperatureThe reaction mixture was refluxed for 1 h
3. customEthanol was evaporated
4. additiondiluted with water
5. filtrationfiltered
6. washwashed with water
7. customThe solid was dried in vacuum at 40° C
8. customThe product was purified by recrystallization from THF and ethyl acetate