Potassium Hydroxide → Potassium 5-chloro-2-fluoro-4-nitrophenolate

HRID 872981Notes

Reaction equation

HRID 872981 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[C:5]([F:9])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[OH-:13].[K+:14]>>[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([F:9])=[C:6]([O-:13])[CH:7]=1.[K+:14]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 101303301-Chloro-4,5-difluoro-2-nitrobenzene

Product 1

HCID 90016791Potassium 5-chloro-2-fluoro-4-nitrophenolate

Procedure

A mixture of 1-chloro-4,5-difluoro-2-nitrobenzene (5.12 g, 26.5 mmol) and 15% aqueous KOH (19.9 g) solution was stirred at reflux for 3 hours, then cooled to rt, and filtered to give the title compound as a yellow crystalloid (5.67 g, 93.3%).

Workup

  1. temperatureat reflux for 3 hours
  2. filtrationfiltered

Sources & evidence

ORD record
ord-77c431dc5e9c4540aa183d9a4446d057
Source dataset
uspto-grants-2015_03
Patent number
US08975282B2

Reaction notes

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