反应详情

温度

120 °C

To a microwave reaction tube 2-(methylamino)ethanol (1.652 g, 22 mmol), 6-chloropyrimidine-2,4(1H,3H)-dione (1.465 g, 10 mmol), potassium iodide (KI) (0.017 g, 0.1 mmol) and water (20 mL) were added. The mixture was heated to 120° C. by microwave (Biotage Initiator) and stirred for 2 h. Then the solution was concentrated in vacuo to remove all the water. EtOH (10 mL) was added to the resultant residue. The suspension was filtered and the filter cake was collected to afford the title compound as a light-yellow solid (1.390 g, 75% yield),

1. additionwere added
2. concentrationThen the solution was concentrated in vacuo
3. customto remove all the water
4. additionEtOH (10 mL) was added to the resultant residue
5. filtrationThe suspension was filtered
6. customthe filter cake was collected