反应详情

To a solution of 1,3-dinitro-5-(trifluoromethyl)benzene (10 g, 42.4 mmol) in absolute methanol (100 mL) was added sodium methanolate (3.43 g, 63.5 mmol) in absolute methanol (20 mL). The red alcoholic solution was refluxed for 1 h, then concentrated to remove solvent, diluted with ethyl acetate (80 mL) and water (30 mL). Separated organic part was dried over Na2SO4, filtered and concentrated to get the title product (8.5 g) as a red solid

1. temperatureThe red alcoholic solution was refluxed for 1 h
2. concentrationconcentrated
3. customto remove solvent
4. additiondiluted with ethyl acetate (80 mL) and water (30 mL)
5. dry with materialSeparated organic part was dried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated