3-Methoxy-5-nitrobenzotrifluoride → 5-(Trifluoromethyl)-m-anisidine

Participants

Reaction Steps

A mixture of 1-methoxy-3-nitro-5-(trifluoromethyl)benzene (8.50 g, 38.4 mmol) and 10% Pd/C (2.00 g, 1.88 mmol) in methanol (40 mL) was stirred under hydrogen balloon at rt for 24 h, and filtered through a pad of celite and concentrated to give the title product (7.2 g) as an orange solid

Provenance & Evidence