反应详情

To a solution of 3-methoxy-5-(trifluoromethyl)benzonitrile (1.30 g, 6.46 mmol) in dry dichloromethane (30 mL) was added BBr3 (0.0920 mL, 0.969 mmol) at 0° C. The reaction mixture was stirred at rt for two days, quenched with 10% sodium bicarbonate (50 mL) and extracted with DCM (2×200 mL). Combined organic portions were dried over anhydrous sodium sulphate and concentrated to afford the title product (1.1 g).

1. customquenched with 10% sodium bicarbonate (50 mL)
2. extractionextracted with DCM (2×200 mL)
3. dry with materialCombined organic portions were dried over anhydrous sodium sulphate
4. concentrationconcentrated