Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylate → HCID 71241187, compound

HRID 873087Notes

Reaction equation

HRID 873087 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:8]=2[C:9]#[N:10])=[CH:4][C:3]=1[C:19]([F:22])([F:21])[F:20].[H-].[Na+].Cl[C:26]1[CH:27]=[C:28]2[N:35]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:34][CH2:33][N:29]2[C:30](=[O:32])[N:31]=1>>[C:39]([O:38][C:36]([N:35]1[C:28]2[N:29]([C:30](=[O:32])[N:31]=[C:26]([O:16][CH2:15][C:12]3[CH:13]=[CH:14][C:7]([O:6][C:5]4[CH:17]=[CH:18][C:2]([Cl:1])=[C:3]([C:19]([F:20])([F:21])[F:22])[CH:4]=4)=[C:8]([C:9]#[N:10])[CH:11]=3)[CH:27]=2)[CH2:33][CH2:34]1)=[O:37])([CH3:42])([CH3:40])[CH3:41]

Participants

3

Reactant 2

HCID 71743561Tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylateHCID 86724172HCID 86724172, compound

Product 1

HCID 71241187HCID 71241187, compound

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 2-(4-chloro-3-(trifluoromethyl)phenoxy)-5-(hydroxymethyl)benzonitrile NaH and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-ea1cf089c5924f179ac85d35b2b538c0
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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