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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 873097Generated: October 29, 2026

Sodium hydride → tert-butyl 7-((4-(4-cyano-3-(trifluoromethyl)phenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

https://huagongshe.com/reaction/873097

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant4-(2-Fluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrileHCID 71239725—
ReactantTert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylateHCID 71743561—
Producttert-butyl 7-((4-(4-cyano-3-(trifluoromethyl)phenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylateHCID 71241003—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, 4-(2-fluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08975400B2
Source datasetuspto-grants-2015_03
ORD IDord-b9bb3f8bdb7b481dbc80957008889f26
Source noteuspto-grants-2015_03