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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 873099Generated: October 29, 2026

Sodium hydride → tert-butyl 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-5-oxo-2,3 dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

https://huagongshe.com/reaction/873099

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant(3-Fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)phenyl)methanolHCID 71239793—
ReactantTert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylateHCID 71743561—
Producttert-butyl 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-5-oxo-2,3 dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylateHCID 71243818—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, (3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)phenyl)methanol and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08975400B2
Source datasetuspto-grants-2015_03
ORD IDord-c25b45481be340bc8de68ad25ecc7dd6
Source noteuspto-grants-2015_03