Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 873104Generated: October 30, 2026

Sodium hydride → tert-butyl 7-((3-fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

https://huagongshe.com/reaction/873104

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant(3-Fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)phenyl)methanolHCID 71239782—
ReactantTert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylateHCID 71743561—
Producttert-butyl 7-((3-fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylateHCID 71243716—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E1 starting from NaH, (3-fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)phenyl)methanol and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08975400B2
Source datasetuspto-grants-2015_03
ORD IDord-3b7d7bb581b0432594fd7e9f50925bf4
Source noteuspto-grants-2015_03