Lithium Hydroxide → HCID 71239887, compound

Participants

Reaction Steps

To a solution of methyl 5-bromo-6-(3-(trifluoromethyl)phenoxy)nicotinate (610 mg, 1.62 mmol) in methanol (4.00 mL), tetrahydrofuran (THF) (4 mL) and water (2.000 mL) was added LiOH (117 mg, 4.87 mmol) at rt. The reaction mixture was stirred at rt for 3 h, quenched with HCl and concentrated. Purification via ISCO system (ethyl acetate/petroleum ether=1/10) afforded the title product (600 mg).

Provenance & Evidence