Hydrochloric Acid → HCID 86724182, compound

Participants

Reaction Steps

A mixture of 3-chloro-4,5-difluorobenzoic acid (0.75 g, 3.9 mmol) and di(1H-imidazol-1-yl)methanone (CDI) (0.695 g, 4.28 mmol) in tetrahydrofuran (THF) (10 mL) was stirred under nitrogen at room temperature for 1 h, and then a solution of NaBH4 (0.221 g, 5.84 mmol) in water (2.0 mL) was added dropwise. The reaction mixture was stirred at 10° C. for 16 h, and adjusted to pH=1 with 1 N HCl solution, concentrated to remove solvent and extracted with ethyl acetate. Separated organic part was washed with a solution of NaHCO3 and concentrated. Purification via preparative TLC afforded the title product (0.41 g).

Provenance & Evidence