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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 873123Generated: October 31, 2026

5-(Hydroxymethyl)-2-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzonitrile → tert-butyl 7-((3-cyano-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

https://huagongshe.com/reaction/873123

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Hydroxymethyl)-2-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzonitrileHCID 66825544—
ReactantTert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-C]pyrimidine-1(5H)-carboxylateHCID 71743561—
Producttert-butyl 7-((3-cyano-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylateHCID 71243820—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E1 starting from 5-(hydroxymethyl)-2-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzonitrile and tert-butyl 7-chloro-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08975400B2
Source datasetuspto-grants-2015_03
ORD IDord-c8a1696e58314616bc4889f52606e0a2
Source noteuspto-grants-2015_03