HCID 86676383, compound → HCID 86724187, compound

Participants

Reaction Steps

To a solution of 4-((2-chloropyridin-4-yl)oxy)-3-fluorobenzaldehyde (580 mg, 2.31 mmol) and dicyanozinc (271 mg, 2.31 mmol) in N,N-dimethylacetamide (DMA) (4 mL) was added tetrakis(triphenylphosphine)palladium(0) (266 mg, 0.230 mmol). The reaction mixture was sealed in a microwave vial and irradiated with a microwave using initial normal to 100° C. for 1 h, and then filtered. Direct purification via reversed phase chromatography (acetonitrile/water: 5%-95%, 0.25% NH4OH) afforded the title product (170 mg) as a white solid.

Provenance & Evidence