(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol → 7-((4-(4-chloro-3-(trifluoromethyl)phenoxy)benzyl)oxy)-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 873176Notes

Reaction equation

HRID 873176 reaction equation
Cl[C:2]1[CH:3]=[C:4]2[N:11]([CH3:12])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[N:7]=1.[Cl:13][C:14]1[CH:28]=[CH:27][C:17]([O:18][C:19]2[CH:24]=[CH:23][C:22]([CH2:25][OH:26])=[CH:21][CH:20]=2)=[CH:16][C:15]=1[C:29]([F:32])([F:31])[F:30]>>[Cl:13][C:14]1[CH:28]=[CH:27][C:17]([O:18][C:19]2[CH:20]=[CH:21][C:22]([CH2:25][O:26][C:2]3[CH:3]=[C:4]4[N:11]([CH3:12])[CH2:10][CH2:9][N:5]4[C:6](=[O:8])[N:7]=3)=[CH:23][CH:24]=2)=[CH:16][C:15]=1[C:29]([F:30])([F:31])[F:32]

Participants

3

Reactant 2

HCID 66825563(4-(4-Chloro-3-(trifluoromethyl)phenoxy)phenyl)methanolHCID 717434587-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one

Product 1

HCID 712411927-((4-(4-chloro-3-(trifluoromethyl)phenoxy)benzyl)oxy)-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Procedure

The title compound was prepared by a procedure similar to those described for E1 starting from 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one and (4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)methanol.

Sources & evidence

ORD record
ord-01d3a4a380164f3baaf7ed9acba3f447
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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