HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-(2-Cyano-4-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)phenoxy)-2-fluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(2-Cyano-4-(hydroxymethyl)phenoxy)-2-fluorobenzonitrile | HCID 71236604 | — |
| Reactant | 7-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one | HCID 71743458 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(2-Cyano-4-(((1-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)phenoxy)-2-fluorobenzonitrile | HCID 71495314 | — |
Reaction Steps
Prepared in a manner similar to that described for E1 using sodium hydride (9.37 mg, 0.234 mmol), 4-(2-cyano-4-(hydroxymethyl)phenoxy)-2-fluorobenzonitrile (41.9 mg, 0.156 mmol) in THF (8 mL) and 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimi-din-5(1H)-one (29 mg, 0.156 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975400B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-5e6ab4c246c44887a8788169622b1731 |
| Source note | uspto-grants-2015_03 |