HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 7-((4-((2-chloropyridin-4-yl)oxy)-3-fluorobenzyl)oxy)-1-methyl-2,3-dihydroimidaz-o[1,2-c]pyrimidin-5(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 7-Chloro-1-methyl-2,3-dihydroimidazo[1,2-C]pyrimidin-5(1H)-one | HCID 71743458 | — |
| Reactant | (4-((2-Chloropyridin-4-yl)oxy)-3-fluorophenyl)methanol | HCID 86724216 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-((4-((2-chloropyridin-4-yl)oxy)-3-fluorobenzyl)oxy)-1-methyl-2,3-dihydroimidaz-o[1,2-c]pyrimidin-5(1H)-one | HCID 86724215 | — |
Reaction Steps
Prepared in a manner similar to that described for E1 using 7-chloro-1-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (50 mg, 0.269 mmol), sodium hydride (21.55 mg, 0.539 mmol) and (4-((2-chloropyridin-4-yl)oxy)-3-fluorophenyl)methanol (68.3 mg, 0.269 mmol) in DMF (2 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975400B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-d2200cf849404e25a483e642980827fe |
| Source note | uspto-grants-2015_03 |