HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 7-((4-(4-cyano-3-(trifluoromethyl)phenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate → 4-(2-Fluoro-4-(((5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)p-hen-oxy)-2-(trifluoromethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 7-((4-(4-cyano-3-(trifluoromethyl)phenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate | HCID 71241003 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-Fluoro-4-(((5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)p-hen-oxy)-2-(trifluoromethyl)benzonitrile | HCID 71243795 | — |
Reaction Steps
Prepared in a manner similar to that described for E71 using tert-butyl 7-((4-(4-cyano-3-(trifluoromethyl)phenoxy)-3-fluorobenzyl)oxy)-5-oxo-2,3-dihydroimidazo[1,2-c]pyrim-idine-1-(5H)-carboxylate (75 mg, 0.137 immol) in DMF (2 mL) and silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975400B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-cb813e7ca82c4b80abe42884a72c9dfd |
| Source note | uspto-grants-2015_03 |