Lithium hydroxide, monohydrate → HCID 11545669, compound

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Reaction Steps

Compound 107m was prepared likewise Method D starting from 106m (21.03 g, 90% pure by 1H NMR, 37.3 mmol) and LiOH.H2O (7.83 g, 187 mmol) to give, after recrystallization from iPr2O/heptane, 107m (12.15 g, 83%) as white granules. mp=78-85° C. 1H NMR: δ 2.37 (t, J=7.4 Hz, 4H), 2.18-2.10 (m, 4H), 1.65-1.45 (m, 20H), 1.29-1.25 (m, 8H). 13C NMR: δ 211.5, 184.8 (2×), 54.0 (2×), 42.4 (2×), 38.9 (2×), 35.9 (4×), 29.2 (2×), 25.5 (2×), 24.9 (4×), 23.5 (2×). Anal. calcd for C23H38O5: C, 70.02; H, 9.71. found: C, 70.37; H, 9.72.

Provenance & Evidence