HCID 11450791, compound → HCID 11290828, compound

Participants

Reaction Steps

To a solution of 211i (2.42 g, 7.02 mmol) in acetic acid (10 mL) was added dropwise sodium hypochlorite solution (1.76 mL, ca. 3.5 mmol) at 18° C. Additional sodium hypochlorite solution (3×1.0 mL, ca. 6.0 mmol) was added after 20, 40, and 60 min under monitoring by TLC. The reaction was quenched with 2-propanol (4 mL) and diluted with deionized water (100 mL). The reaction mixture was extracted with ethyl acetate (3×60 mL). The combined organic layers were washed with saturated NaHCO3 solution (3×60 mL), water (60 mL) and brine (60 mL), dried over anhydrous MgSO4, and concentrated in vacuo. Purification of the crude product (2.38 g) by column chromatography (silica gel, ethyl acetate/hexanes=1/1) gave 214i (0.83 g, 35%) as a colorless wax. 1H NMR (CDCl3): δ (ppm): 3.33 (s, 4H), 2.41 (t, J=7.4, 4 μl), 1.85 (br, 2H), 1.62-1.45 (m, 4H), 1.35-1.18 (m, 16H), 0.87 (s, 12H). 13C NMR (CDCl3): δ (ppm): 212.09, 72.10, 42.99, 38.75, 35.20, 30.48, 29.42, 24.05, 23.99, 23.82. HRMS (LSIMS, gly): Calcd for C21H43O3 (MH+): 343.3212, found: 343.3208. HPLC: 96.4% pure.

Provenance & Evidence