Dimethyl Sulfoxide → [5-(2-Imidazol-1-yl-pyridin-4-yl)-4-methyl-thiazol-2-yl]-pyrazin-2-yl-amine

HRID 87337Notes

Reaction equation

HRID 87337 reaction equation
[C:26](=[O:27])([O-:28])[O-:29].[CH3:32][S:33]([CH3:34])=[O:35].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9]([CH3:20])[n:10][c:11]([NH:13][c:14]3[n:15][cH:16][cH:17][n:18][cH:19]3)[s:12]2)[cH:7]1.[Cs+:30].[Cs+:31].[OH2:36].[nH:21]1[cH:22][n:23][cH:24][cH:25]1>>[c:2]1(-[n:21]2[cH:22][n:23][cH:24][cH:25]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9]([CH3:20])[n:10][c:11]([NH:13][c:14]3[n:15][cH:16][cH:17][n:18][cH:19]3)[s:12]2)[cH:7]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 795ImidazoleHCID 962WaterHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 11301149[5-(2-Chloro-pyridin-4-yl)-4-methyl-thiazol-2-yl]-pyrazin-2-yl-amine

Product 1

HCID 11232938[5-(2-Imidazol-1-yl-pyridin-4-yl)-4-methyl-thiazol-2-yl]-pyrazin-2-yl-amine

Sources & evidence

ORD record
ord-59a6d4e03f81402297fa5bf8b356acfd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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