tert-Butanol → 1-(2-Ethyl-butyl)-cyclohexanecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

A stream of 1-(2-ethyl-butyl)-cyclohexanecarbonitrile (0.5 g, 2.59 mmol) in tert-butanol (12.5 mL, 0.2 M, flow=0.18 mL/min; Knauer WellChrom HPLC K-501 pump) was combined with a second stream containing aqueous sodium hydroxide solution (2.0 M, 50 mL, flow=0.70 mL/min; Knauer WellChrom HPLC K-501 pump) using a custom made static micromixer (internal volume ca. 0.1 mL). The resulting mixture was directed through a stainless steel coil reactor (volume=53 mL, ID=2.1 mm; Supelco 304 stainless steel; nominal residence time of 1 h, which doesn't take the volume expansion of the solvent mixture into account) equipped with a total back pressure valve of 2500 psi and heated to 280° C. by means of a HP 6890 Series GC Oven System.

Provenance & Evidence