Hydrochloric Acid → HCID 117700766, compound

Participants

Reaction Steps

Lithium hydroxide monohydrate (303 mg, 7.21 mmol) was added to a solution of the methyl 6-[4-methoxy-2-methyl-3-(3,3,6,6-tetramethyl-1,8-dioxo-2,3,4,5,6,7,8,9-octahydro-1H-xanthen-9-yl)phenyl]-3-[(trimethylsilyl)ethynyl]pyridine-2-carboxylate produced in Example 12-2 (564 mg, 0.90 mmol) in THF (11 ml) and water (5.5 ml) at room temperature, and the mixture thus obtained was then stirred at the same temperature as above for 17 hours. Thereafter, a 1 N aqueous solution of hydrochloric acid (7.21 ml) was added to the reaction solution, and water was then added thereto. The solution thus mixed was then extracted with dichloromethane. The organic layer thus obtained was dried over anhydrous sodium sulfate. The solvent was distilled away under reduced pressure, and the solid thus obtained was then washed with a mixed solution of diethyl ether and hexane, followed by collection by filtration and drying, to obtain the title compound (435 mg, yield: 89%).

Provenance & Evidence